Description
Order Bremelanotide, PT141 ,CAS No.:32780-32-8 online
Bremelanotide (formerly PT-141) is a compound under drug development by Palatin Technologies as a treatment for female sexual dysfunction, hemorrhagic shock and reperfusion injury. It functions by activating the melanocortin receptors MC1R and MC4R, to modulate inflammation and limiting ischemia. It was originally tested for intranasal administration in treating female sexual dysfunction but this application was temporarily discontinued in 2008 after concerns were raised over adverse side effects of increased blood pressure. As of March, 2012, Palatin is conducting a human Phase 2B study using a new subcutaneous drug delivery system that appears to have little effect on blood pressure.
Bremelanotide or PT-141 is the generic term for a new research peptide for use in helping improve sexual dysfunction in men (erectile dysfunction or impotence) as well as helping improve sexual dysfunction in women (sexual arousal disorder). Bremelanotide, PT-141 does not act on the vascular system like the former compounds but it is known and has been shown to help increase sexual activity in both male and female mammals. Bremelanotide PT-141 allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation. PT-141, bremelanotide is experimental and is used for the purpose of sexual arousal. It is a melanocortin based peptide that has shown effectiveness in clinical studies on both male and female rats. Male rats have shown erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive results with higher doses around 2-3 mgs. While the dosage requirements tend to be higher for female rats, the observable results in female rats tend to be stronger.
PT-141 (Bremelanotide) is that the 1st of a replacement category of medicine referred to as melanocortin agonists being developed to treat sexual pathology. The mechanism of action of PT-141 (Bremelanotide) could provide important safety and effectualness edges over presently obtainable product as a result of it acts on the pathway that controls sexual operate while not acting directly on the system. Clinical information indicates that PT-141 (Bremelanotide) could also be effective in treating a broad vary of patients tormented by impotence. The nasal formulation of PT-141 (Bremelanotide) being developed is as convenient as oral treatments, is a lot of patient-friendly than invasive treatments for impotence, like injections and trans-urethral pellets, and seems to lead to a fast onset of action.
About PT-141
Bremelanotide (PT-141) was developed from Melanotan a pair of (MT-II). PT-141 may be a substance of MT-II that lacks the C-terminal organic compound function-stripping away tanning properties.
PT-141 is that the solely artificial aphrodisiac. Studies have shown Bremelanotide to be effective in treating sexual pathology in each men (erectile pathology or impotence) and ladies (sexual arousal disorder). not like anit-impotence drug and alternative connected medications (PDE5s), PT-141 doesn’t bear on the system, however directly through the systema nervosum (hypothalamus) to extend need. Viagra, Cials and Levitra aren’t thought-about aphrodisiacs as they are doing not have any direct impact on the physical attraction. However, treatment with PDE5 inhibitors and PT-141 ar well-known to possess a synergistic impact.
Bremelanotide may be a melanocortin amide secretion. PT-141 binds to the melanocortin four receptor (MC4R) specially within the brain. 9 out of 10 volunteers experienced arousal in trials. The aphrodisiac effects of Bremelanotide ar during a category of its own.
Bremelanotide comes in 10mg and 2mg phial sizes. Peptides photographed at right ar synthesized by an equivalent laboratory, contain no filler and so the distinction is visible. Freeze dried Melanotan peptides (PT-141) ar terribly sturdy and stable. Most PT-141 comes within the trade commonplace 10mg size. The 2mg PT-141 is employed a lot of as a travel amide or couples dose. As a way of life amide, the 10mg product may be a heap to consume and will worship to twenty doses once dosing lightweight. The PT-141 amide reconstituted with biological process water remains potent within the refrigerator for months. Nasal sprays, pre-mixed PT-141, pills and loose powder aren’t legitimate. There ar winning reports of snorting and nasal spray experiences…however they’re few and much between.
Bremelanotide, injected (subcutaneously), contains a distinctive window of chance lasting six to seventy two hours. In science lab trials feminine rats exposed to PT-141 began “flirting” with male rats for sex. Postures and movements left little doubt within the male rats minds that they were within the mood. The human PT-141 date is one wherever the dose precedes the activity by a minimum of one or two hours. once the celebs align, hours when the injection, …this is your window of chance, enjoy.
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