Description
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CJC-1295 is a tetrasubstituted 30-amino acid peptide hormone, primarily functioning as a growth hormone releasing hormone (GHRH) analog.
One of the advantages of CJC-1295 over traditional GHRH or rHGH is its ability to bioconjugate with serum albumin, thus increasing its half-life and therapeutic window. It accomplishes this by using protecting groups around the amino acids of GHRH typically susceptible to enzymatic degradation.
CAS No. 863288-34-0
Other Names GHRH
MF C165H269N47O46
Type Pharmaceutical Intermediates, Syntheses Material Intermediates
Purity over 99.5%
Application health
Appearance dried powder
Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF,GHRF), somatoliberin or somatocrinin, is a releasing hormone for growth hormone. It is a 44-amino acidpeptide hormone produced in the arcuate nucleus of the hypothalamus.
GHRH first appears in the human hypothalamus between 18 and 29 weeks of gestation, which corresponds to the start of production of growth hormone and other somatotropes in fetuses.
GHRH is released from neurosecretory nerve terminals of these arcuate neurons, and is carried by the hypothalamo-hypophyseal portal system to theanterior pituitary gland where it stimulates growth hormone (GH) secretion by stimulating the growth hormone-releasing hormone receptor. GHRH is released in a pulsatile manner, stimulating similar pulsatile release of GH. In addition, GHRH also promotes slow-wave sleep directly. Growth hormone is required for normal postnatal growth, bone growth, regulatory effects on protein, carbohydrate, and lipid metabolism.
GHRH stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary.
Main article: Growth hormone-releasing hormone receptor
The GHRHR is a member of the secretin family of G protein-coupled receptors, and is located on chromosome 7. This protein is transmembranous with seven folds, and its molecular weight is approximately 44 kD.
GHRH binding to GHRHR results in increased GH production mainly by the cAMP dependent pathway, but also by the phospholipase C pathway (IP3/DAG pathway), and other minor pathways.
The cAMP-dependent pathway is initiated by GHRH binding to its receptor, causing receptor conformation that activates Gs alpha subunit of the closely associated G-Protein complex on the intracellular side. This results in stimulation of membrane-bound adenylyl cyclase and increased intracellular cyclic adenosine monophosphate (cAMP). cAMP binds to and activates the regulatory subunits of protein kinase A (PKA), allowing the free catalytic subunits to translocate to the nucleus and phosphorylate the transcription factor cAMP response element binding protein (CREB). Phosphorylated CREB, together with its coactivators, p300 and CREB binding protein (CBP) enhances the transcription of GH by binding to CREs cAMP-response elements in the promoter region of the GH gene. It also increases transcription of the GHRHR gene, providing positive feedback.
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