Description
FTPP (Aditpotide) is an experimental weight loss peptidomimetic, which has been developed by researchers in the United States in an effort to combat obesity. Peptidomimetics are small protein-like chains designed to mimic a peptide. This experimental treatment has reportedly reduced the weight BMI and waist circumference of the treated monkeys by 11%.
Clinical research studies in the U.S. have shown that the peptide-like compound Adipotide is able to kill fat cells, this causes a decrease in the volume and mass of the subcutaneous fat, which in turn leads to weight loss.
FTPP (Adipotide) is able to kill the fat cells by selectively causing programmed cell death of the blood vessels supplying them. Due to the deprivation of nutrient supply and the accumulation of waste products in the fat cells, an irreversible injury occurs and this causes the mitochondria to release protease enzymes called caspases which activate a process whereby DNA is used to create mRNA and a process whereby mRNA is used to create the nascent primary peptide of gene sequences which ultimately leads to the production of proteins that cause fat cell death.
Fat Targetted Proapoptotic Peptide (FTPP) profile:
Adipotide is a synthetic peptide designed to react with adipose tissue vascular endothelials and initiate apoptosis (programed cell death). This mechanism kills vascular cells in adipose tissue. Withouth regular blood supply to fat cells weight loss is initiated through apetite suppression and fat cell degenaration. In studies with monkey it was found to cause reversible kidney proximal tubule function disruption.
Description:
2.4 kDa poly-peptide containing 26 amino acid residues.
CKGGRAKDCGGDKLAKLAKKLAKLAK-NH2 (CKGGRAKDC-GG-D(KLAKLAK)2)
Synonyms:
Adipotide, FTPP, Fat Targetted Proapoptotic Peptide.
Physical Appearance:
Sterile Filtered White lyophilized (freeze-dried) powder.
Specificity:
Adipotide (FTPP) has an affinity to endothelial receptors in adipose tissue/ initiation of apoptosis.
Purity:
>99.8% (HPLC analyzed).
Solubility:
Add 1 ml of sterile diluent and let the lyophilized pellet dissolve completely.
Stability:
Store lyophilized protein at -20 °C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 °C for a limited period of time. The lyophilized protein remains stable until the expiry date when stored at -20 °C.
